Alex, The Leukodystrophy Charity (Alex TLC) provides invaluable support and information to people affected by leukodystrophy. Leukodystrophies are genetic disorders that mainly affect the white matter of the central nervous system (i.e. the brain or spinal cord). There are more than 100 different known types of leukodystrophy, including some so rare they only affect one or two individuals. Established in 2004 we are an internationally recognised centre of excellence and the only UK charity providing support and information to people affected by any of the leukodystrophy conditions worldwide.